Cadmium-induced kidney injury: Oxidative damage as a unifying mechanism
LJ Yan, DC Allen - Biomolecules, 2021 - mdpi.com
Cadmium is a nonessential metal that has heavily polluted the environment due to human
activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory …
activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory …
Targeting the interplay of autophagy and ROS for cancer therapy: An updated overview on phytochemicals
L Dong, J He, L Luo, K Wang - Pharmaceuticals, 2023 - mdpi.com
Autophagy is an evolutionarily conserved self-degradation system that recycles cellular
components and damaged organelles, which is critical for the maintenance of cellular …
components and damaged organelles, which is critical for the maintenance of cellular …
Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway
QY Lu, LJ Yang, JJ Xiao, Q Liu, LH Ni, JW Hu… - Free Radical Biology …, 2023 - Elsevier
Renal tubular damage plays a key role in the pathogenesis of diabetic kidney disease
(DKD), and one of the main pathological process associated with DKD in diabetic mice is the …
(DKD), and one of the main pathological process associated with DKD in diabetic mice is the …
The antioxidative effects of empagliflozin on high glucose‑induced epithelial-mesenchymal transition in peritoneal mesothelial cells via the Nrf2/HO-1 signaling
P Shi, Z Zhan, X Ye, Y Lu, K Song, F Sheng, H Shen… - Renal failure, 2022 - Taylor & Francis
High glucose (HG)-induced epithelial-mesenchymal transition (EMT) and oxidative stress
play an important role in peritoneal fibrosis, which could be regulated by the nuclear factor …
play an important role in peritoneal fibrosis, which could be regulated by the nuclear factor …
[HTML][HTML] Neohesperidin alleviates the inhibitory effect of bisphenol A on the myogenic differentiation of umbilical cord mesenchymal stem cells via the IGF1R/AKT1 …
J Yang, S Qin, N Sun, Y Cai, J Li, Z Zhai, J An… - Ecotoxicology and …, 2024 - Elsevier
Bisphenol A (BPA), a typical environmental endocrine disruptor, has raised concerns among
researchers due to its toxicological effects. Whether neohesperidin (NEO) can intervene in …
researchers due to its toxicological effects. Whether neohesperidin (NEO) can intervene in …
Research progress on the role and inhibitors of Keap1 signaling pathway in inflammation
C Ding, Y Wu, C Zhan, A Naseem, L Chen, H Li… - International …, 2024 - Elsevier
Inflammation is a protective mechanism against endogenous and exogenous pathogens. It
is a typical feature of numerous chronic diseases and their complications. Keap1 is an …
is a typical feature of numerous chronic diseases and their complications. Keap1 is an …
Amelioration of diabetic kidney injury with dapagliflozin is associated with suppressing renal HMGB1 expression and restoring autophagy in obese mice
B Feng, F Yang, J Liu, Q Sun, R Meng, D Zhu - Journal of diabetes and its …, 2023 - Elsevier
Diabetic kidney disease (DKD) is a major cause of chronic and end-stage renal disease in
diabetic patients. Here, we investigated protective effects and possible mechanisms of …
diabetic patients. Here, we investigated protective effects and possible mechanisms of …
Pinostrobin, a dietary bioflavonoid exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against methotrexate-induced ovarian toxicity in rats
This study investigated the protective activities of pinostrobin (PIN) against methotrexate
(MTX)-induced ovarian toxicity. Female rats were administered with PIN (50 mg/kg) for 4 …
(MTX)-induced ovarian toxicity. Female rats were administered with PIN (50 mg/kg) for 4 …
Empagliflozin-A Sodium Glucose Co-transporter-2 Inhibitor: Overview of its Chemistry, Pharmacology, and Toxicology
Background: Empagliflozin is a sodium glucose co-transporter-2 (SGLT2) inhibitor that has
gained significant attention in the treatment of type 2 diabetes mellitus. Understanding its …
gained significant attention in the treatment of type 2 diabetes mellitus. Understanding its …
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice
D He, X Gao, J Wen, Y Zhang, S Yang, X Sun, M Cui… - Food & Function, 2024 - pubs.rsc.org
Parkinson's disease (PD), a neurodegenerative disease, is the leading cause of movement
disorders. Neuroinflammation plays a critical role in PD pathogenesis. Neohesperidin (Neo) …
disorders. Neuroinflammation plays a critical role in PD pathogenesis. Neohesperidin (Neo) …