Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Increases in the life expectancy of people with Intellectual Disability have followed similar
trends to those found in the general population. With the exception of people with severe …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

Evidence is reviewed for a developmentally‐emerging behavioral phenotype in individuals
with Down syndrome that includes significant delay in nonverbal cognitive development …

Down syndrome (DS) is a major cause of mental retardation and congenital heart disease.
Besides a characteristic set of facial and physical features, DS is associated with congenital …

Research in developmental phonological disorders, particularly emerging subgroup studies
using behavioral and molecular genetics, requires qualitative and continuous measurement …

Previous research has hypothesized an association between Alzheimer's disease and the
amyloid precursor protein (APP) gene found on chromosome 21. We report the case of a 78 …

Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down
syndrome (DS) has been linked to increased brain amyloid levels and early-onset …

Down Syndrome is a condition brought about by an extra copy of a segment of the long arm
of Chromosome 21 that is associated with characteristic physical features and cognitive …

Down syndrome is the most prevalent cause of intellectual impairment associated with a
genetic anomaly, in this case, trisomy of chromosome 21. It affects both physical and …