Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating
Krebs' cycle intermediates that alter transcription of immune response genes. We extended …

Objective Thalamic atrophy is among the earliest brain changes detected in patients with
multiple sclerosis (MS) and the degree of thalamic atrophy is a strong predictor of disability …

Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central
nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form …

While there is a great clinical need to understand the biology of metastatic cancer in order to
treat it more effectively, research is hampered by limited sample availability. Research …

Background: Detecting cortical demyelination using magnetic resonance imaging (MRI) in
multiple sclerosis (MS) remains a challenge. Magnetization transfer ratio (MTR), T1 …

The proinflammatory cytokine IFN-γ, which is chronically elevated in multiple sclerosis,
induces pathologic quiescence in human oligodendrocyte progenitor cells (OPCs) via …

Objective Microglia/macrophages line the border of demyelinated lesions in both cerebral
white matter and the cortex in the brains of multiple sclerosis patients. Microglia …

Objective Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative
disease of the central nervous system (CNS). Though MS was initially considered to be a …

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central
nervous system, where ongoing demyelination and remyelination failure are the major …

Abstract Magnetic Resonance Imaging (MRI) can provide the location and signal
characteristics of pathological regions within a postmortem tissue block, thereby improving …