Recent advances in biosynthesis and regulatory mechanisms of principal mycotoxins

M Ferrara, G Perrone, A Gallo - Current Opinion in Food Science, 2022 - Elsevier
Highlights•An update on molecular mechanisms behind the biosynthesis of main
mycotoxins.•Global and cluster-specific regulatory elements govern mycotoxin …

Genomic and phenotypic trait variation of the opportunistic human pathogen Aspergillus flavus and its close relatives

EA Hatmaker, M Rangel-Grimaldo, HA Raja… - Microbiology …, 2022 - Am Soc Microbiol
Fungal diseases affect millions of humans annually, yet fungal pathogens remain
understudied. The mold Aspergillus flavus can cause both aspergillosis and fungal keratitis …

Current approaches for advancement in understanding the molecular mechanisms of mycotoxin biosynthesis

A Gallo, G Perrone - International Journal of Molecular Sciences, 2021 - mdpi.com
Filamentous fungi are able to synthesise a remarkable range of secondary metabolites,
which play various key roles in the interaction between fungi and the rest of the biosphere …

Secondary metabolism gene clusters exhibit increasingly dynamic and differential expression during asexual growth, conidiation, and sexual development in …

Z Wang, F Lopez-Giraldez, J Slot, O Yarden, F Trail… - Msystems, 2022 - Am Soc Microbiol
Secondary metabolite clusters (SMCs) encode the machinery for fungal toxin production.
However, understanding their function and analyzing their products requires investigation of …

Potential antifungal targets based on histones post-translational modifications against invasive aspergillosis

Y Li, Z Song, E Wang, L Dong, J Bai, D Wang… - Frontiers in …, 2022 - frontiersin.org
As a primary cause of death in patients with hematological malignancies and transplant
recipients, invasive aspergillosis (IA) is a condition that warrants attention. IA infections have …