RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells
Z Zhang, Z Yao, L Wang, H Ding, J Shao, A Chen… - Autophagy, 2018 - Taylor & Francis
Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid
peroxidation. However, the molecular mechanisms regulating ferroptosis are largely …
peroxidation. However, the molecular mechanisms regulating ferroptosis are largely …
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy
HY Chen, ZZ Xiao, X Ling, RN Xu, P Zhu, SY Zheng - Molecular Medicine, 2021 - Springer
Aims Myocardial ischemia is the most common form of cardiovascular disease and the
leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for …
leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for …
Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
F Yang, A Hu, D Li, J Wang, Y Guo, Y Liu, H Li, Y Chen… - Molecular cancer, 2019 - Springer
Abstract Background Circular RNAs (circRNAs), a subclass of non-coding RNAs, play
essential roles in tumorigenesis and aggressiveness. Our previous study has identified that …
essential roles in tumorigenesis and aggressiveness. Our previous study has identified that …
The ribonucleic complex HuR-MALAT1 represses CD133 expression and suppresses epithelial–mesenchymal transition in breast cancer
E Latorre, S Carelli, I Raimondi, V D'Agostino… - Cancer research, 2016 - AACR
Epithelial-to-mesenchymal transition (EMT) is a core process underlying cell movement
during embryonic development and morphogenesis. Cancer cells hijack this developmental …
during embryonic development and morphogenesis. Cancer cells hijack this developmental …
Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
N Ripin, J Boudet, MM Duszczyk… - Proceedings of the …, 2019 - National Acad Sciences
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …
Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression
Z Zou, T Ma, X He, J Zhou, H Ma, M Xie, Y Liu… - Cell death & …, 2018 - nature.com
Substantial evidence shows that long non-coding RNAs (lncRNAs) participate in many
biological mechanisms, and their dysregulation are also involved in the development and …
biological mechanisms, and their dysregulation are also involved in the development and …
[HTML][HTML] Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
FF Blanco, R Preet, A Aguado, V Vishwakarma… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-
related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional …
related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional …
HuR controls glutaminase RNA metabolism
D Adamoski, L M. dos Reis, ACP Mafra… - Nature …, 2024 - nature.com
Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target
for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) …
for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) …