One of the greatest obstacles to current cancer treatment efforts is the development of drug
resistance by tumors. Despite recent advances in diagnostic practices and surgical …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

In the past century, gradual but sustained advances in our understanding of the molecular
mechanisms involved in the growth and invasive properties of cancer cells have led to better …

The epithelial-to-mesenchymal transition (EMT) is crucial for the migration and invasion of
many epithelial tumors, including prostate cancer. Although it is known that ZEB1 …

Androgens play pivotal roles in the regulation of male development and physiological
processes, particularly in the male reproductive system. Most biological effects of androgens …

Background Although androgens are depleted in castration resistant prostate cancer
(CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated …

Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and
androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally …

The discovery of androgen dependence in prostate cancer in 1941 by Huggins and
colleagues has remained the backbone for the treatment of this disease. However, although …

The transcriptional programs regulated through the activity of the androgen receptor (AR)
modulate normal prostate development and the maintenance of prostatic functions at …

The understanding of the key role that androgens play on the normal and pathological
physiology of the prostate guided the development of different therapies for the treatment of …