Shadow enhancers are seemingly redundant transcriptional cis-regulatory elements that
regulate the same gene and drive overlapping expression patterns. Recent studies have …

Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …

Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Here, we document a collection of∼ 7434 MiMIC (Minos Mediated Integration Cassette)
insertions of which 2854 are inserted in coding introns. They allowed us to create a library of …

Transcriptional enhancers are crucial regulators of gene expression and animal
development and the characterization of their genomic organization, spatiotemporal …

During embryogenesis, precise gene transcription in space and time requires that distal
enhancers and promoters communicate by physical proximity within gene regulatory …

Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing
the evolutionary history of anatomically modern humans. However, historic migrations from …

The sense of smell enables animals to react to long-distance cues according to learned and
innate valences. Here, we have mapped with electron microscopy the complete wiring …

Instructions for when, where and to what level each gene should be expressed are encoded
within regulatory sequences. The importance of motifs recognized by DNA-binding …