Enhancer redundancy in development and disease
Shadow enhancers are seemingly redundant transcriptional cis-regulatory elements that
regulate the same gene and drive overlapping expression patterns. Recent studies have …
regulate the same gene and drive overlapping expression patterns. Recent studies have …
Neuronal cell-type classification: challenges, opportunities and the path forward
Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …
believe that the only realistic way to manage this complexity—and thereby pave the way for …
Transcriptional enhancers: from properties to genome-wide predictions
Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …
expression. These are established by the coordinated action of genomic regulatory …
[HTML][HTML] Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
[HTML][HTML] A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila
S Nagarkar-Jaiswal, PT Lee, ME Campbell, K Chen… - elife, 2015 - elifesciences.org
Here, we document a collection of∼ 7434 MiMIC (Minos Mediated Integration Cassette)
insertions of which 2854 are inserted in coding introns. They allowed us to create a library of …
insertions of which 2854 are inserted in coding introns. They allowed us to create a library of …
Genome-scale functional characterization of Drosophila developmental enhancers in vivo
Transcriptional enhancers are crucial regulators of gene expression and animal
development and the characterization of their genomic organization, spatiotemporal …
development and the characterization of their genomic organization, spatiotemporal …
[HTML][HTML] Regulatory landscaping: how enhancer-promoter communication is sculpted in 3D
During embryogenesis, precise gene transcription in space and time requires that distal
enhancers and promoters communicate by physical proximity within gene regulatory …
enhancers and promoters communicate by physical proximity within gene regulatory …
Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing
the evolutionary history of anatomically modern humans. However, historic migrations from …
the evolutionary history of anatomically modern humans. However, historic migrations from …
[HTML][HTML] The wiring diagram of a glomerular olfactory system
The sense of smell enables animals to react to long-distance cues according to learned and
innate valences. Here, we have mapped with electron microscopy the complete wiring …
innate valences. Here, we have mapped with electron microscopy the complete wiring …
In pursuit of design principles of regulatory sequences
Instructions for when, where and to what level each gene should be expressed are encoded
within regulatory sequences. The importance of motifs recognized by DNA-binding …
within regulatory sequences. The importance of motifs recognized by DNA-binding …