Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Closing the gap between 19F and 18F chemistry

J Ajenjo, G Destro, B Cornelissen… - EJNMMI Radiopharmacy …, 2021 - Springer
Positron emission tomography (PET) has become an invaluable tool for drug discovery and
diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET …

Recent progress in the application of iodonium ylides in organic synthesis

X Mi, C Pi, W Feng, X Cui - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Iodonium ylides have attracted considerable attention due to their unique properties and
numerous applications as versatile and sustainable reagents in organic synthesis …

Positron emission tomography imaging of the endocannabinoid system: opportunities and challenges in radiotracer development

L Hou, J Rong, A Haider, D Ogasawara… - Journal of medicinal …, 2020 - ACS Publications
The endocannabinoid system (ECS) is involved in a wide range of biological functions and
comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis …

Arene radiofluorination enabled by photoredox-mediated halide interconversion

W Chen, H Wang, NES Tay, VA Pistritto, KP Li… - Nature …, 2022 - nature.com
Positron emission tomography (PET) is a powerful imaging technology that can visualize
and measure metabolic processes in vivo and/or obtain unique information about drug …

Recent Progress in Synthetic Applications of Hypervalent Iodine (III) Reagents

A Yoshimura, VV Zhdankin - Chemical Reviews, 2024 - ACS Publications
Hypervalent iodine (III) compounds have found wide application in modern organic
chemistry as environmentally friendly reagents and catalysts. Hypervalent iodine reagents …

Fluorine-18: A radionuclide with diverse range of radiochemistry and synthesis strategies for target based PET diagnosis

NS Goud, RK Joshi, RD Bharath, P Kumar - European Journal of Medicinal …, 2020 - Elsevier
Fluorine-18 is one of the most widely used radionuclides for the production of
radiopharmaceuticals for positron emission tomography (PET). The radiolabeling methods …

Exploring the role of halogen bonding in iodonium ylides: insights into unexpected reactivity and reaction control

CA Montgomery, GK Murphy - Beilstein Journal of Organic …, 2023 - beilstein-journals.org
Halogen bonding is commonly found with iodine-containing molecules, and it arises when
Lewis bases interact with iodine's σ-holes. Halogen bonding and σ-holes have been …

State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis

LYF Haveman, DJ Vugts, AD Windhorst - EJNMMI Radiopharmacy and …, 2023 - Springer
Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and
clinical nuclear imaging technique used in disease diagnosis and therapy assessment …

Synthesis of high-molar-activity [18F]6-fluoro-l-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor

AV Mossine, SS Tanzey, AF Brooks, KJ Makaravage… - Nature protocols, 2020 - nature.com
Abstract [18F] 6-fluoro-l-DOPA ([18F] FDOPA) is a diagnostic radiopharmaceutical for
positron emission tomography (PET) imaging that is used to image Parkinson's disease …