Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

One of the earliest and best-recognized elements of atherosclerosis is its close relationship
with circulating LDL (low-density lipoprotein). There is convincing evidence that LDL …

Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to
thrombin generation during blood coagulation by proteolytic activation of several …

Although anticoagulants have been in use for more than 80 years, heparin and vitamin K
antagonists were the sole available options until recently. Although these agents …

Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia and is associated with
significant morbidity and mortality. There is plenty of evidence available to support the …

Chronic kidney disease is present in almost 10% of the world population and is associated
with excess mortality and morbidity. Reduced glomerular filtration rate and the presence and …

Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …

Abstract Background Factor XI (FXI) inhibition offers the promise of hemostasis‐sparing
anticoagulation for the prevention and treatment of thromboembolic events. Abelacimab …

Heparin‐induced thrombocytopenia (HIT) is a life‐threatening prothrombotic, immune‐
mediated complication of unfractionated heparin and low molecular weight heparin therapy …

Abstract IONIS‐FXIRX (BAY2306001) is an antisense oligonucleotide that inhibits the
synthesis of coagulation factor XI (FXI) and has been investigated in healthy volunteers and …