Altered cell adhesion and glycosylation promote cancer immune suppression and metastasis

H Läubli, L Borsig - Frontiers in immunology, 2019 - frontiersin.org
Cell-cell interactions and cell adhesion are key mediators of cancer progression and
facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many …

Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins

G Bendas, L Borsig - International journal of cell biology, 2012 - Wiley Online Library
Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell‐
cell interactions of cancer cells with endothelium determine the metastatic spread. In …

Transmembrane mucins: signaling receptors at the intersection of inflammation and cancer

JPM van Putten, K Strijbis - Journal of innate immunity, 2017 - karger.com
Mucosal surfaces line our body cavities and provide the interaction surface between
commensal and pathogenic microbiota and the host. The barrier function of the mucosal …

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

IG Winkler, V Barbier, B Nowlan, RN Jacobsen… - Nature medicine, 2012 - nature.com
The microenvironment, or niche, surrounding a stem cell largely governs its cellular fate.
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone …

Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

L Zhong, MJ Simard, J Huot - The FASEB Journal, 2018 - Wiley Online Library
The surface of endothelial cells is covered with cell adhesion molecules, including E‐
selectin, intercellula adhesion molecule 1 (ICAM‐1), and vascular cell adhesion molecule 1 …

Unmasking fucosylation: from cell adhesion to immune system regulation and diseases

J Li, HC Hsu, JD Mountz, JG Allen - Cell chemical biology, 2018 - cell.com
Fucosylation is a biological process broadly observed in vertebrates, invertebrates, plants,
bacteria, and fungi. Fucose moieties on cell-surface glycans are increasingly recognized as …

Selectins promote tumor metastasis

H Läubli, L Borsig - Seminars in cancer biology, 2010 - Elsevier
Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

[HTML][HTML] The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells

I Corre, F Paris, J Huot - Oncotarget, 2017 - ncbi.nlm.nih.gov
By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a
central role in regulating cardiovascular functions and systemic homeostasis and in …

Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems

JS Jeon, S Bersini, JA Whisler, MB Chen… - Integrative …, 2014 - academic.oup.com
The generation of functional microvascular networks is critical for the development of
advanced in vitro models to replicate pathophysiological conditions. Mural cells provide …

Molecular interactions in cancer cell metastasis

SA Brooks, HJ Lomax-Browne, TM Carter, CE Kinch… - Acta histochemica, 2010 - Elsevier
Metastasis, the process by which cancer cells leave the primary tumour, disseminate and
form secondary tumours at anatomically distant sites, is a serious clinical problem as it is …