Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …

Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the
alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich …

RBM20 (RNA-binding motif protein 20) is a vertebrate-and muscle-specific RNA-binding
protein that belongs to the serine-arginine-rich family of splicing factors. The RBM20 gene …

Dilated cardiomyopathy is the second most common cause for heart failure with no cure
except a high-risk heart transplantation. Approximately 30% of patients harbor heritable …

Abstract Arginine–serine (RS) domain (s) in splicing factors are critical for protein–protein
interaction in pre‐mRNA splicing. Phosphorylation of RS domain is important for splicing …

RBM20 is one of the genes predisposing to dilated cardiomyopathy (DCM). Variants in the
RS domain have been reported in many DCM patients, but the pathogenicity of variants …

Cardiovascular system diseases, as aortic valve stenosis, are the main cause of mortality
and morbidity among patients. There is still a room for enhancement of the diagnostic and …

Human patients carrying genetic mutations in RNA binding motif 20 (RBM20) develop a
clinically aggressive dilated cardiomyopathy (DCM). Genetic mutation knockin (KI) animal …

Cardiovascular diseases are the leading cause of mortality in the world, mainly due to
atherosclerosis and its consequences. The article presents the numerical model of the blood …