The biogenesis and functions of piRNAs in human diseases

X Wu, Y Pan, Y Fang, J Zhang, M Xie, F Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …

Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases

M Li, Y Yang, Z Wang, T Zong, X Fu, LHH Aung… - Angiogenesis, 2021 - Springer
Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Increasing
reports demonstrated that non-coding RNAs (ncRNAs) have been crucially involved in the …

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA

XQ Gao, YH Zhang, F Liu, M Ponnusamy, XM Zhao… - Nature cell …, 2020 - nature.com
PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy.
However, their functions and molecular mechanisms remain unknown. Here, we identified a …

PIWI‐Interacting RNA HAAPIR Regulates Cardiomyocyte Death After Myocardial Infarction by Promoting NAT10‐Mediated ac4C Acetylation of Tfec mRNA

K Wang, LY Zhou, F Liu, L Lin, J Ju, PC Tian… - Advanced …, 2022 - Wiley Online Library
PIWI‐interacting RNAs (piRNAs) are abundantly expressed in heart. However, their
functions and molecular mechanisms during myocardial infarction remain unknown. Here, a …

Non-coding RNAs in human cancer and other diseases: overview of the diagnostic potential

R Beňačka, D Szabóová, Z Guľašová… - International journal of …, 2023 - mdpi.com
Non-coding RNAs (ncRNAs) are abundant single-stranded RNA molecules in human cells,
involved in various cellular processes ranging from DNA replication and mRNA translation …

Extracellular Vesicle (EVs) associated non-coding RNAs in lung cancer and therapeutics

A Paramanantham, R Asfiya, S Das, G McCully… - International journal of …, 2022 - mdpi.com
Lung cancer is one of the most lethal forms of cancer, with a very high mortality rate. The
precise pathophysiology of lung cancer is not well understood, and pertinent information …

The long and short of it: the emerging roles of non-coding RNA in small extracellular vesicles

A Abramowicz, MD Story - Cancers, 2020 - mdpi.com
Small extracellular vesicles (EVs) play a significant role in intercellular communication
through their non-coding RNA (ncRNA) cargo. While the initial examination of EV cargo …

Circulating extracellular vesicles as biomarkers and drug delivery vehicles in cardiovascular diseases

RCC de Freitas, RDC Hirata, MH Hirata, E Aikawa - Biomolecules, 2021 - mdpi.com
Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane and
soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles) …

Identification of piRNA targets in urinary extracellular vesicles for the diagnosis of prostate cancer

Q Peng, PKF Chiu, CYP Wong, CKL Cheng, JYC Teoh… - Diagnostics, 2021 - mdpi.com
Emerging studies demonstrate that PIWI-interacting RNAs (piRNAs) are associated with
various human cancers. This study aimed to evaluate the urinary extracellular vesicles (EVs) …

Extracellular endothelial cell-derived vesicles: emerging role in cardiac and vascular remodeling in heart failure

AE Berezin, AA Berezin - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Extracellular vesicles play a pivotal role in numerous physiological (immune response, cell-
to-cell cooperation, angiogenesis) and pathological (reparation, inflammation, thrombosis …