Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural
and physiological outputs that are easy to directly measure. Key neural elements for …

Patient-specific computer models have been developed representing a variety of aspects of
the cardiovascular system spanning the disciplines of electrophysiology, electromechanics …

This editorial introduces the Special Issue on Simulation and Synthesis in Medical Imaging.
In this editorial, we define so-far ambiguous terms of simulation and synthesis in medical …

Cardiac electrophysiology models have been developed for over 50 years, and now include
detailed descriptions of individual ion currents and sub-cellular calcium handling. It is …

Key points Mathematical and computational models of cardiac physiology have been an
integral component of cardiac electrophysiology since its inception, and are collectively …

Models of cardiac mechanics are increasingly used to investigate cardiac physiology. These
models are characterized by a high level of complexity, including the particular anisotropic …

Recent efforts to ensure the reliability of computational model-based predictions in
healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty …

Breathing in mammals is a seemingly straightforward behaviour controlled by the brain. A
brainstem nucleus called the preBötzinger Complex sits at the core of the neural circuit …

Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …

This work presents an open-source software pipeline to create patient-specific left atrial
models with fibre orientations and a fibrDEFAULTosis map, suitable for electrophysiology …