Memory T cells are characterized by their low activation threshold, robust effector functions,
and resistance to conventional immunosuppression and costimulation blockade. Unlike their …

Activation of CD4 T cells by B cells has been extensively studied, but B cell-regulated
priming, proliferation, and survival of CD8 T cells remains controversial. B cells express high …

Immunoglobulin A (IgA) is an important factor in maintaining homeostasis at mucosal
surfaces, yet luminal IgA levels vary widely. Total IgA levels are thought to be driven by …

BACKGROUND Idiopathic CD4 lymphopenia (ICL) is defined by persistently low CD4+ cell
counts (< 300 cells/μL) in the absence of a causal infection or immune deficiency and can …

We previously showed increased growth associated protein 43 (GAP-43) expression in
brain samples resected from patients with cortical dysplasia (CD), which was correlated with …

One of the biggest barriers to achieving allograft tolerance is the presence of immunological
memory within the recipient, which confers a faster, more robust immune response that is in …

Prolonged cold ischemia storage (CIS) is a leading risk factor for poor transplant outcome.
Existing strategies strive to minimize ischemia–reperfusion injury in transplanted organs, yet …

Antibody-mediated rejection is a major cause of long-term graft loss in kidney transplant
patients. T follicular helper (Tfh) cells are crucial for assisting B cell differentiation and are …

Diminishing homeostatic proliferation of memory T cells is essential for improving the
efficacy of lymphoablation in transplant recipients. Our previous studies in a mouse heart …

Immunologic memory is the ability of adaptive immune system to quickly and specifically
recognize previously encountered antigens and initiate an effector response. Alloreactive …