Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification

Å Johansson, OA Andreassen, S Brunak… - Journal of internal …, 2023 - Wiley Online Library
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …

Stimuli‐responsive organic near‐infrared photoacoustic probes

Q Shen, L Wang, X Ruan, N Li, W Wang… - Advanced Functional …, 2023 - Wiley Online Library
Photoacoustic (PA) imaging is an emerging biomedical imaging technique with the features
of non‐invasiveness and non‐ionization. It takes advantage of the photothermal effect of PA …

Combination of exercise and GLP-1 receptor agonist treatment reduces severity of metabolic syndrome, abdominal obesity, and inflammation: a randomized …

RM Sandsdal, CR Juhl, SBK Jensen… - Cardiovascular …, 2023 - Springer
Background Identifying and reducing cardiometabolic risks driven by obesity remains a
healthcare challenge. The metabolic syndrome is associated with abdominal obesity and …

Contribution of specific ceramides to obesity-associated metabolic diseases

P Hammerschmidt, JC Brüning - Cellular and Molecular Life Sciences, 2022 - Springer
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Obesity and cardiovascular disease: an ESC clinical consensus statement

KC Koskinas, EM Van Craenenbroeck… - European Heart …, 2024 - academic.oup.com
The global prevalence of obesity has more than doubled over the past four decades,
currently affecting more than a billion individuals. Beyond its recognition as a high-risk …

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles

SM Davidson, CM Boulanger, E Aikawa… - Cardiovascular …, 2023 - academic.oup.com
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from
cells of the cardiovascular system, and are considered important mediators of intercellular …

Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology …

C Antoniades, D Tousoulis, M Vavlukis… - European heart …, 2023 - academic.oup.com
Obesity is a modifiable cardiovascular risk factor, but adipose tissue (AT) depots in humans
are anatomically, histologically, and functionally heterogeneous. For example, visceral AT is …

Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets

L Badimon, T Padro, G Arderiu, G Vilahur… - Immunological …, 2022 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global
mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular …

Insulin: The master regulator of glucose metabolism

L Norton, C Shannon, A Gastaldelli, RA DeFronzo - Metabolism, 2022 - Elsevier
Insulin is the master regulator of glucose, lipid, and protein metabolism. Following ingestion
of an oral glucose load or mixed meal, the plasma glucose concentration rises, insulin …

[HTML][HTML] Metabolomics of extracellular vesicles: a future promise of multiple clinical applications

YL Wu, WJ Chen, M Guo, Q Tan, E Zhou… - International Journal …, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) can contain DNA, RNA, proteins and metabolic molecules from
primary origins; they are coated with a phospholipid bilayer membrane and released by …