Unwinding the roles of RNA helicase MOV10

A Nawaz, T Shilikbay, G Skariah… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
MOV10 is an RNA helicase that associates with the RNA‐induced silencing complex
component Argonaute (AGO), likely resolving RNA secondary structures. MOV10 also binds …

Ten years of enhancing neuro‐imaging genetics through meta‐analysis: An overview from the ENIGMA Genetics Working Group

SE Medland, KL Grasby, N Jahanshad… - Human Brain …, 2022 - Wiley Online Library
Here we review the motivation for creating the enhancing neuroimaging genetics through
meta‐analysis (ENIGMA) Consortium and the genetic analyses undertaken by the …

[HTML][HTML] Cellular correlates of cortical thinning throughout the lifespan

D Vidal-Pineiro, N Parker, J Shin, L French… - Scientific reports, 2020 - nature.com
Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration,
yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology …

Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration

C Estevez-Fraga, A Altmann, CS Parker, RI Scahill… - Brain, 2023 - academic.oup.com
Cortical cell loss is a core feature of Huntington's disease (HD), beginning many years
before clinical motor diagnosis, during the premanifest stage. However, it is unclear how …

[HTML][HTML] Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis

AD Grotzinger, TT Mallard, Z Liu, J Seidlitz, T Ge… - Nature …, 2023 - nature.com
Recent work in imaging genetics suggests high levels of genetic overlap within cortical
regions for cortical thickness (CT) and surface area (SA). We model this multivariate system …

[HTML][HTML] Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance

DE Vosberg, I Jurisica, Z Pausova, T Paus - Nature Communications, 2024 - nature.com
Tangential growth of the human cerebral cortex is driven by cell proliferation during the first
and second trimester of pregnancy. Fetal growth peaks in mid-gestation. Here, we explore …

Cortical profiles of numerous psychiatric disorders and normal development share a common pattern

Z Cao, RB Cupertino, J Ottino-Gonzalez, A Murphy… - Molecular …, 2023 - nature.com
The neurobiological bases of the association between development and psychopathology
remain poorly understood. Here, we identify a shared spatial pattern of cortical thickness …

[HTML][HTML] Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

C Sarnowski, M Ghanbari, JC Bis, M Logue… - Communications …, 2022 - nature.com
Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors
for tauopathies and related neurological disorders. Here, we confirmed and better …

[HTML][HTML] Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age

J Xu, J Shin, M McGee, S Unger, N Bando… - The American Journal of …, 2022 - Elsevier
Background Mechanisms responsible for associations between intake of mother's milk in
very-low-birth-weight (VLBW,< 1500 g) infants and later neurodevelopment are poorly …

[HTML][HTML] General psychopathology, cognition, and the cerebral cortex in 10-year-old children: insights from the adolescent brain cognitive development study

Y Patel, N Parker, GA Salum, Z Pausova… - Frontiers in Human …, 2022 - frontiersin.org
General psychopathology and cognition are likely to have a bidirectional influence on each
other. Yet, the relationship between brain structure, psychopathology, and cognition remains …