Membrane-bound organelles allow cells to traffic cargo and separate and regulate
metabolic pathways. While many organelles are generated by the growth and division of …

The lives of thousands premature babies have been saved along the last thirty years thanks
to the establishment and consolidation of pulmonary surfactant replacement therapies …

The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

The adenosine 5′-triphosphate (ATP)–binding cassette (ABC) transporter ABCA3 plays a
critical role in pulmonary surfactant biogenesis. Mutations in human ABCA3 have been …

Writing a career retrospective for this prestigious series is a huge challenge. Is my story
really of that much interest? One thing that is different about my life in science is the heavy …

Pathogenic variants in surfactant proteins SP-B and SP-C cause surfactant deficiency and
interstitial lung disease. Surfactant proteins are synthesized as precursors (proSP-B, proSP …

Idiopathic pulmonary fibrosis is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. Several lung …

The cuticle of C. elegans is impermeable to chemicals, toxins, and pathogens. However,
increased permeability is a desirable phenotype because it facilitates chemical uptake …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal degenerative lung disease of
unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell …

Tibetan sheep have lived on the Qinghai-Tibet Plateau for a long time, and after long-term
natural selection, they have shown stable genetic adaptability to high-altitude environments …