CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …

The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …

Breast cancer resistance protein (BCRP/ABCG2), an ATP-binding cassette (ABC) efflux
transporter, plays a critical role in multi-drug resistance (MDR) to anti-cancer drugs and drug …

Background: Breast Cancer (BC) is the second most common cause of cancer related
deaths in women. Due to severe side effects and multidrug resistance, current therapies like …

ATP-binding cassette (ABC) transporters are pivotal for cell detoxification and survival.
Overexpression of ABC transporter in tumor cells lead to chemoresistance through the efflux …

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …

Breast cancer (BC) is the most common cancer for females and its incidence tends to
increase year by year. Currently, the backbone of therapy for BC is mainly chemotherapy …

The ATP-binding cassette transporter ABCG2 mediates the efflux of several
chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in …

We synthesize various substituted triazole-containing flavonoids and identify potent,
nontoxic, and highly selective BCRP inhibitors. Ac18Az8, Ac32Az19, and Ac36Az9 possess …