Chemokine receptor-ligand interaction regulates transmigration of lymphocytes and
monocytes from circulation to the inflammatory sites. CC chemokine receptors, chemokine …

Abstract Development of drug resistance in P. falciparum is one of the major problems
associated with malaria treatment. Parasite genetic factors such as single nucleotide …

Identification of potential drug targets as well as development of novel antimalarial
chemotherapies with unique mode of actions due to drug resistance by Plasmodium …

The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic
development of the human malaria parasite Plasmodium falciparum. PfCRT resides at the …

For the development of new and potent antimalarial drugs, we designed the virtual library
with three points of randomization of novel [1, 2, 4] triazolo [4, 3-a] pyridines bearing a …

Purpose The resistance of parasite to readily affordable antimalarial drugs, the high cost of
currently potent drugs, and the resistance of vector mosquitoes to insecticides threaten the …

Continually emerging resistant strains of malarial parasites to current drugs present
challenges. Understanding the underlying resistance mechanisms, especially those linked …

Chemokine receptors and ligands are crucial for extensive immune response against
infectious diseases such as malaria, leishmaniasis, HIV and tuberculosis and a wide variety …

Plasmodium falciparum malaria, which degrades haemoglobin through falcipain-2 (FP2), is
a serious disease killing 445 thousand people annually. Since the P. falciparum's survival in …

Despite the countless efforts made in the last decades, malaria and neglected tropical
diseases remain a high-impact health problem in developing countries. Malaria is one of the …