Membrane microdomains (rafts) remain one of the controversial issues in biophysics.
Fluorescent molecular probes, which make these lipid nanostructures visible through optical …

Ceramides are sphingolipids containing a sphingosine or a related base, to which a fatty
acid is linked through an amide bond. When incorporated into a lipid bilayer, ceramides …

Applying pulsed excitation together with time-gated detection improves the fluorescence on-
off contrast in continuous-wave stimulated emission depletion (CW-STED) microscopy, thus …

The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine
kinase receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and …

Cell membranes are typically very complex, consisting of a multitude of different lipids and
proteins. Supported lipid bilayers are widely used as model systems to study biological …

The principles of organization and functioning of cellular membranes are currently not well
understood. The raft hypothesis suggests the existence of domains or rafts in cell …

Cell membranes are not randomly organized, but rather are populated by fluctuating
nanoassemblies of increased translational order termed lipid rafts. This lateral heterogeneity …

Investigation of lipid lateral mobility in biological membranes and their artificial models
provides information on membrane dynamics and structure; methods based on optical …

Systematically dissecting the molecular basis of the cell surface as well as its related
biological activities is considered as one of the most cutting-edge fields in fundamental …

Cholesterol (Chol) plays the essential function of regulating the physical properties of the
cell membrane by controlling the lipid organization and phase behavior and, thus, managing …