Alcoholic liver disease: pathogenesis and new therapeutic targets
B Gao, R Bataller - Gastroenterology, 2011 - Elsevier
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can
lead to fibrosis and cirrhosis. The latest surveillance report published by the National …
lead to fibrosis and cirrhosis. The latest surveillance report published by the National …
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …
Fructose promotes leaky gut, endotoxemia, and liver fibrosis through ethanol‐inducible cytochrome P450‐2E1–mediated oxidative and nitrative stress
Fructose intake is known to induce obesity, insulin resistance, metabolic syndrome, and
nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose …
nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose …
Nitric oxide in liver diseases
Y Iwakiri, MY Kim - Trends in Pharmacological sciences, 2015 - cell.com
Nitric oxide (NO) and its derivatives play important roles in the physiology and
pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of …
pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of …
Manganese superoxide dismutase and oxidative stress modulation
G Bresciani, IBM da Cruz… - Advances in clinical …, 2015 - Elsevier
Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production
and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system …
and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system …
Role of oxidative stress in alcohol-induced liver injury
AI Cederbaum, Y Lu, D Wu - Archives of toxicology, 2009 - Springer
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …
in small amounts during the body's metabolic reactions and can react with and damage …
Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy …
Cyclophosphamide (CP) is a common chemotherapeutic agent that is effective against a
wide variety of tumors. The associated hepatotoxicity and nephrotoxicity, however, limit its …
wide variety of tumors. The associated hepatotoxicity and nephrotoxicity, however, limit its …
Alcohol, oxidative stress and free radical damage
E Albano - Proceedings of the nutrition society, 2006 - cambridge.org
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …
[PDF][PDF] Alcohol and oxidative liver injury
A Dey, AI Cederbaum - Hepatology, 2006 - Wiley Online Library
Acute and chronic ethanol treatment has been shown to increase the production of reactive
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …
Pathogenesis of alcoholic liver disease
W Dunn, VH Shah - Clinics in liver disease, 2016 - liver.theclinics.com
Alcoholic liver disease (ALD) includes a broad spectrum of disorders, such as simple
steatosis, cirrhosis, acute alcoholic hepatitis (AH) with or without cirrhosis, and …
steatosis, cirrhosis, acute alcoholic hepatitis (AH) with or without cirrhosis, and …