Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Agents that interfere with tubulin function have a broad anti-tumor spectrum and they
represent one of the most significant classes of anticancer agents. In the past few years …

A structure–activity relationship (SAR) guided design of novel tubulin polymerization
inhibitors has resulted in a series of benzo [b] furans with exceptional potency toward cancer …

The synthesis and antiproliferative activity of a new series of rigid analogues of
combretastatin A-4 are described which contain the 1, 4-diaryl-2-azetidinone (β-lactam) ring …

New arylthioindole derivatives having different cyclic substituents at position 2 of the indole
were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization …

An efficient method for regio-and chemoselective Friedel–Crafts acylation of indole using
acyl chlorides in the presence of ZrCl4 has been discovered. It minimizes/eliminates …

A visible-light-induced synthesis of 3-acylindoles from simple indoles and α-oxo acids at
room temperature has been discovered. The reaction tolerates a wide range of functional …

A visible-light photoredox synthesis of 3-acylindoles through intramolecular oxidative
cyclization of o-alkynylated N, N-dialkylamines is developed. The reaction proceeds …