Abstract γ-aminobutyric acid type B (GABA B) receptors are broadly expressed in the
nervous system and play an important role in neuronal excitability. GABA B receptors are G …

Intracranial self-stimulation (ICSS) is a behavioral procedure in which operant responding is
maintained by pulses of electrical brain stimulation. In research to study abuse-related drug …

Tobacco smoking causes high rates of mortality and morbidity throughout the world. Despite
the availability of smoking-cessation medications, maintenance of long-term abstinence is …

Allosteric receptor modulation is an attractive concept in drug targeting because it offers
important potential advantages over conventional orthosteric agonism or antagonism …

Current pharmacotherapies for addiction represent opportunities for facilitating treatment
and are forming a foundation for evaluating new medications. Furthermore, validated animal …

This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …

Nicotine is the primary component of tobacco that maintains the smoking habit and develops
addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated …

Abstract γ-Aminobutyric acid B (GABA B) receptors and their ligands are postulated as
potential therapeutic targets for the treatment of several brain disorders, including drug …

The present paper summarizes the preclinical and clinical studies conducted to define the
“anti-alcohol” pharmacological profile of the prototypic GABAB receptor agonist, baclofen …

Tobacco use is predicted to result in over 1 billion deaths worldwide by the end of the 21st
century. How genetic variation contributes to the observed differential predisposition in the …