Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

This article presents an overview of time-resolved (lifetime) fluorescence techniques used in
biomedical diagnostics. In particular, we review the development of time-resolved …

When light is incident to a biological tissue surface, combinations of optical processes occur,
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …

The study of biological systems in their real environmental conditions is crucial to decipher
the true image of structures and processes underlying their functionality. In this regard …

Background Fluorescence lifetime imaging (FLIM) is a novel imaging technique that
generates image contrast between different states of tissue due to differences in …

Objective. In the USA, detection of intestinal metaplasia is a requirement for enrolment in
surveillance programmes for dysplasia or adenocarcinoma in columnar-lined oesophagus …

We report the design and development of a compact optical fiber-based apparatus for in situ
time-resolved laser-induced fluorescence spectroscopy (tr-LIFS) of biological systems. The …

The application of time-resolved fluorescence spectroscopy (TRFS) to in vivo tissue
diagnosis requires a method for fast acquisition of fluorescence decay profiles in multiple …

2007-11-13 Assigned to SEARETE, LLC reassignment SEARETE, LLC ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEAVER, THOMAS …

BACKGROUND: Light-induced fluorescence endoscopy (LIFE) may improve the detection of
high-grade dysplasia (HGD) and early stage cancer (EC) in Barrett's esophagus (BE). The …