Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

A peptic ulcer is a sore on the lining of the stomach or duodenum. The two most common
types of peptic ulcer are called “gastric ulcers” and “duodenal ulcers”. Peptic ulcers are …

Gastrin is a pro-proliferative, anti-apoptotic hormone with a central role in acid secretion in
the gastric mucosa and a long-standing association with malignant progression in …

The dramatic success of pharmacological acid suppression in healing peptic ulcers and
managing patients with gastroesophageal reflux disease (GERD) has been reflected in the …

DNA methylation is a regulatory mechanism in epigenetics that is frequently altered during
human carcinogenesis. To detect critical methylation events associated with gastric cancer …

In our inbred strain of cotton rats (Sigmodon hispidus) 50% of the females develop
spontaneous ECL cell-derived tumors in the acid-producing part of the stomach due to …

Gastrin was the second hormone to be postulated to exist (1) shortly after Bayliss & Starling
(2) developed the concept of blood-borne chemical signal substances based upon their …

Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation
of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal …

A number of CCK2 antagonists have been reported to play an important role in controlling
gastric acid-related conditions, nervous system related disorders and certain types of …

Background: Gastrin and cholecystokinin (CCK) receptors are trophic for various
gastrointestinal malignancies. Their role in gallbladder cancer has not been widely studied …