Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Background There is a striking latitudinal gradient in multiple sclerosis (MS) prevalence, but
exceptions in Mediterranean Europe and northern Scandinavia, and some systematic …

The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal
position 6p21 that encodes the six classical transplantation HLA genes and at least 132 …

Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of
demyelination and axonal lesion mediated by CD4+ T cells with a proinflammatory Th1 and …

Objective: To examine whether obesity during childhood, adolescence, or adulthood is
associated with an increased risk of multiple sclerosis (MS). Methods: Women in the Nurses' …

Although strong genetic determinants of multiple sclerosis (MS) exist, the findings of
migration studies support a role for environmental factors in this disease. Through rigorous …

Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …

Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease with a complex
clinical course characterized by inflammation, demyelination, and axonal degeneration …