Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …

Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

An asymmetric palladium and copper co‐catalyzed Heck/Sonogashira reaction between o‐
iodoacrylanilides and terminal alkynes to synthesize chiral oxindoles was developed. In …

Due to the composed α-helical/β-strand structures, β-amyloid peptide (Aβ) is sensitive to
chiral environments. The orientation and chirality of the Aβ strand strongly influence its …

Molecular metal/NH bifunctional Noyori-type catalysts are remarkable in that they are among
the most efficient artificial catalysts developed to date for the hydrogenation of carbonyl …

A new strategy has been developed for the oxidant‐and base‐free dehydrogenative
coupling of N‐heterocycles at mild conditions. Under the action of an iridium catalyst, N …

Sulfonamide linker-based inhibitors with extended linear structure were designed and
synthesized with the aim of producing multifunctional agents against several processes …

Aggregation and the formation of oligomeric intermediates of amyloid-β (Aβ) at the
membrane interface of neuronal cells are implicated in the cellular toxicity and pathology of …

Recent advances in the application of environmentally benign acid catalysts in organic
synthesis are reviewed. The work includes three main parts;(i) description of …

Alzheimer's disease characterized by misfolding, aggregation, and accumulation of amyloid
fibrils in an insoluble form in the brain, is often known as amyloidosis. The process of …