Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Harnessing the potential beneficial effects of kinase signalling through the generation of
direct kinase activators remains an underexplored area of drug development,,,–. This also …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Recent studies have provided long-sought evidence that behavioural learning involves
specific synapse gain and elimination processes, which lead to memory traces that influence …

Reactive oxygen species (ROS) have long been studied as destructive agents in the context
of nervous system ageing, disease and degeneration. Their roles as signalling molecules …

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …

Rett Syndrome is a neurodevelopmental disorder that arises from mutations in the X-linked
gene methyl-CpG binding protein 2 (MeCP2). MeCP2 has a large number of targets and a …

The phosphatidylinositol-3-kinase/phosphatase and tensin homolog (PTEN)-mammalian
target of rapamycin (mTOR) pathway regulates a variety of neuronal functions, including cell …

Environmental manipulations can enhance neuroplasticity in the brain, with enrichment‐
induced cognitive improvements being linked to increased expression of growth factors …