The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Microbes can be engineered to act like living therapeutics designed to perform specific
actions in the human body. From fighting and preventing infections to eliminating tumors and …

Endolysins and their derivatives have emerged in recent years as a novel class of
antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and …

Targeted killing of pathogenic bacteria without harming beneficial members of host
microbiota holds promise as a strategy to cure disease and limit both antimicrobial-related …

Bacteria exist as communities in diverse multispecies environments. Quorum sensing, a
process for cell–cell communication, allows individual bacteria to glean information about …

Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that
enable bacteria to sense and respond to physical, chemical, and biological stimuli outside …

Highlights•Probiotics can be engineered to develop live biotherapeutics in case of no
efficacy of the wild-type strains.•Probiotics have been engineered to treat diseases such as …

Water contamination by pathogenic bacteria is a major public health concern globally.
Monitoring bacterial contamination in water is critically important to protect human health …

The human body is a natural habitat for a multitude of microorganisms, with bacteria being
the major constituent of the microbiota. These bacteria colonize discrete anatomical …