While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule …

Highlights•Atypical B cells (ABCs) are expanded in malaria and autoimmune
diseases..•ABCs are similar in malaria and SLE but likely play disease-specific roles.•They …

Chronic infectious diseases have a substantial impact on the human B cell compartment
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …

Anemia is a common complication of malaria that is characterized by the loss of infected and
uninfected erythrocytes. In mouse malaria models, clearance of uninfected erythrocytes is …

The B cell activating factor (BAFF) inhibitor, belimumab, is the first biologic drug approved for
the treatment of SLE, and exhibits modest, but durable, efficacy in decreasing disease flares …

Two seminal observations suggest that the African genome contains genes selected by
malaria that protect against systemic lupus erythematosus (SLE) in individuals chronically …

Antibody repertoire sequencing enables researchers to acquire millions of B cell receptors
and investigate these molecules at the single-nucleotide level. This power and resolution in …

The quest for immune correlates of protection continues to slow vaccine development. To
date, only vaccine-induced antibodies have been confirmed as direct immune correlates of …

Highlights•IgM, but not IgD, downregulation is a shared feature of autoreactive B cells.•IgD is
less sensitive to endogenous antigens and monovalent antigens than IgM.•IgM and IgD …

Humoral immunity is a critical effector arm for protection against malaria but develops only
slowly after repeated infections. T cell-mediated regulatory dynamics affect the development …