The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

In 2017, it is two hundred years since James Parkinson provided the first complete clinical
description of the disease named after him, fifty years since the introduction of high-dose D …

Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Abstract α-synuclein aggregation is implicated in a variety of diseases including Parkinson's
disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy …

Physiologically, α-synuclein chaperones soluble NSF attachment protein receptor (SNARE)
complex assembly and may also perform other functions; pathologically, in contrast, α …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

Parkinson's disease is a devastating neurological condition that affects at least four million
people. A striking feature of this disorder is the preferential loss of dopamine-producing …

In recent years, two developments have imparted a new direction to research on the
aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense …