Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease
The adult heart is a complex, multicellular organ that is subjected to a series of regulatory
stimuli and circuits and has poor reparative potential. Despite progress in our understanding …
stimuli and circuits and has poor reparative potential. Despite progress in our understanding …
Machine learning for catalysing the integration of noncoding RNA in research and clinical practice
D de Gonzalo-Calvo, K Karaduzovic-Hadziabdic… - …, 2024 - thelancet.com
The human transcriptome predominantly consists of noncoding RNAs (ncRNAs), transcripts
that do not encode proteins. The noncoding transcriptome governs a multitude of …
that do not encode proteins. The noncoding transcriptome governs a multitude of …
Long non-coding RNAs in cardiac hypertrophy and heart failure: Functions, mechanisms and clinical prospects
The surge in reports describing non-coding RNAs (ncRNAs) has focused attention on their
possible biological roles and effects on development and disease. ncRNAs have been …
possible biological roles and effects on development and disease. ncRNAs have been …
HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients
S Greco, A Made', M Mutoli, L Zhang, SN Piella… - Journal of Translational …, 2023 - Springer
Background Even after 3 years from SARS-CoV-2 identification, COVID-19 is still a
persistent and dangerous global infectious disease. Significant improvements in our …
persistent and dangerous global infectious disease. Significant improvements in our …
Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
Y Devaux, L Zhang, AI Lumley… - Nature …, 2024 - nature.com
Tools for predicting COVID-19 outcomes enable personalized healthcare, potentially easing
the disease burden. This collaborative study by 15 institutions across Europe aimed to …
the disease burden. This collaborative study by 15 institutions across Europe aimed to …
Circular RNA regulatory role in pathological cardiac remodelling
Cardiac remodelling involves structural, cellular and molecular alterations in the heart after
injury, resulting in progressive loss of heart function and ultimately leading to heart failure …
injury, resulting in progressive loss of heart function and ultimately leading to heart failure …
[HTML][HTML] Exploring the translational landscape of the long noncoding RNA transcriptome in acute respiratory distress syndrome: it is a long way to the top
T Belmonte, C Rodríguez-Muñoz… - European …, 2024 - publications.ersnet.org
Acute respiratory distress syndrome (ARDS) poses a significant and widespread public
health challenge. Extensive research conducted in recent decades has considerably …
health challenge. Extensive research conducted in recent decades has considerably …
[HTML][HTML] Firalink: a bioinformatics pipeline for long non-coding RNA data analysis
L Chauviere, L Hoffbeck, M Shoaib, F Tessier… - Non-coding RNA …, 2023 - Elsevier
The Firalink bioinformatics pipeline has been developed to analyse long non-coding RNA
(lncRNA) data generated by targeted sequencing. This pipeline has been first implemented …
(lncRNA) data generated by targeted sequencing. This pipeline has been first implemented …
Prediction of COVID‐19 severity using machine learning
K Karaduzovic‐Hadziabdic, M Adilovic… - Clinical and …, 2024 - pmc.ncbi.nlm.nih.gov
Dear Editor, Prediction of COVID-19 severity is a critical task in the decision-making process
during the initial stages of the disease, enabling personalised surveillance and care of …
during the initial stages of the disease, enabling personalised surveillance and care of …
[PDF][PDF] HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients
AI Lumley, AP Beltrami, PK Srivastava, V Milani… - 2023 - … -medicine.biomedcentral.com
Background Even after 3 years from SARS-CoV-2 identification, COVID-19 is still a
persistent and dangerous global infectious disease. Significant improvements in our …
persistent and dangerous global infectious disease. Significant improvements in our …