The mineralocorticoid receptor (MR) is a nuclear receptor and part of a large and diverse
family of transcription factors that also includes receptors for glucocorticoids, progesterone …

The formation of 19-hydroxydeoxycorticosterone (19, 21-dihydroxy-4-pregnen-3, 20-dione),
19-oxo-deoxycorticosterone (21-hydroxy-4-pregnen-3, 19, 20-trione), and 19-oic …

Dahl's salt‐resistant normotensive rats (DR rats) have been previously reported to express
cytochrome P‐450 (CYP11B1) containing five missense mutations [Matsukawa, N., Nonaka …

Nonaldosterone mineralocorticoids, such as deoxycorticosterone (DOC) and 18-hydroxy-
DOC, have been reported to be elevated in some patients with primary aldosteronism (PA) …

When 18-hydroxy-11-deoxycorticosterone was incubated with adrenocortical mitochondria
fortified by adding exogenously adrenodoxin reductase and adrenodoxin in the presence of …

Nor-deoxycorticosterone (19-nor-DOC), in the neutral fraction of human urine, was isolated
and quantitated as the acetate derivative using ultraviolet absorption of the peak emerging …

The development of radio-ligands with a high specific activity has greatly facilitated the study
of hormonal receptor systems. These receptor studies have given us insight into the actions …

Abstract 17α-hydroxylase deficiency syndrome (17-OHDS) is associated with
hypogonadism, hypertension, and hypokalemia. Aldosterone production, however, is not …

Oxo-11-deoxycorticosterone was incubated with a cytochrome P-450 11β-reconstituted
system, and the metabolites were analyzed by high performance liquid chromatography …

The effect of absence of the C-19 methyl group from five adrenal steroids has been studied
in terms of their affinity for mineralocorticoid (MR) and glucocorticoid receptors (GR). In MR …