Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
ME Fini, SG Schwartz, X Gao, S Jeong, N Patel… - Progress in retinal and …, 2017 - Elsevier
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …
Application of nanotechnology for sensitive detection of low-abundance single-nucleotide variations in genomic DNA: a review
Single-nucleotide polymorphisms (SNPs) are the simplest and most common type of DNA
variations in the human genome. This class of attractive genetic markers, along with point …
variations in the human genome. This class of attractive genetic markers, along with point …
Physician-reported benefits and barriers to clinical implementation of genomic medicine: a multi-site IGNITE-network survey
A Owusu Obeng, K Fei, KD Levy, AR Elsey… - Journal of personalized …, 2018 - mdpi.com
Genetic medicine is one of the key components of personalized medicine, but adoption in
clinical practice is still limited. To understand potential barriers and provider attitudes, we …
clinical practice is still limited. To understand potential barriers and provider attitudes, we …
Current status and future opportunities in lung precision medicine research with a focus on biomarkers. An American Thoracic Society/National Heart, Lung, and Blood …
AC Wu, JP Kiley, PJ Noel, S Amur… - American journal of …, 2018 - atsjournals.org
Background: Thousands of biomarker tests are either available or under development for
lung diseases. In many cases, adoption of these tests into clinical practice is outpacing the …
lung diseases. In many cases, adoption of these tests into clinical practice is outpacing the …
Advances in stem cell research for the treatment of primary hypogonadism
L Li, V Papadopoulos - Nature Reviews Urology, 2021 - nature.com
In Leydig cell dysfunction, cells respond weakly to stimulation by pituitary luteinizing
hormone, and, therefore, produce less testosterone, leading to primary hypogonadism. The …
hormone, and, therefore, produce less testosterone, leading to primary hypogonadism. The …
Ethical, legal, and social implications of genetic risk prediction for multifactorial disease: a narrative review identifying concerns about interpretation and use of …
CR Chapman - Journal of Community Genetics, 2023 - Springer
Advances in genomics have enabled the development of polygenic scores (PGS),
sometimes called polygenic risk scores, in the context of multifactorial diseases and …
sometimes called polygenic risk scores, in the context of multifactorial diseases and …
Pathology-supported genetic testing for the application of breast cancer pharmacodiagnostics: family counselling, lifestyle adjustments and change of medication
AO Okunola, KJ Baatjes, AE Zemlin… - Expert Review of …, 2023 - Taylor & Francis
Background Pathology-supported genetic testing (PSGT) enables transitioning of risk
stratification from the study population to the individual. Research Design and Methods We …
stratification from the study population to the individual. Research Design and Methods We …
Pioneering BRCA1/2 Point-Of-Care Testing for Integration of Germline and Tumor Genetics in Breast Cancer Risk Management: A Vision for the Future of …
L Mampunye, NC Van der Merwe, KA Grant… - Frontiers in …, 2021 - frontiersin.org
Research performed in South African (SA) breast, ovarian and prostate cancer patients
resulted in the development of a rapid BRCA point-of-care (POC) assay designed as a time …
resulted in the development of a rapid BRCA point-of-care (POC) assay designed as a time …
Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder …
M De Klerk, N Van Der Merwe… - Annals of Human …, 2024 - Wiley Online Library
Introduction An ethics‐guided decision‐making framework was developed for applying
pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that …
pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that …
Globally rare BRCA2 variants with founder haplotypes in the South African population: implications for point-of-care testing based on a single-institution BRCA1/2 next …
J Oosthuizen, MJ Kotze, N Van Der Merwe… - Frontiers in …, 2021 - frontiersin.org
Breast cancer patients historically benefitted from population-based genetic research
performed in South Africa, which led to the development of founder-based BRCA1/2 …
performed in South Africa, which led to the development of founder-based BRCA1/2 …