Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

The mechanical properties of bone are fundamental to the ability of our skeletons to support
movement and to provide protection to our vital organs. As such, deterioration in mechanical …

Background Traditional risk factors are insufficient to explain all cases of coronary artery
disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products …

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent
adducts with the plasma proteins through a non-enzymatic process known as glycation …

Biological materials are typically multifunctional but many have evolved to optimize a chief
mechanical function. These functions include impact or fracture resistance, armor and …

Bone fragility is a major health concern, as the increased risk of bone fractures has
devastating outcomes in terms of mortality, decreased autonomy, and healthcare costs …

Collagen is a ubiquitous protein with remarkable mechanical properties. It is highly elastic,
shows large fracture strength and enables substantial energy dissipation during …

Collagen is the principal biopolymer in the extracellular matrix of both vertebrates and
invertebrates. It is produced in specialized cells (fibroblasts) and extracted into the body by a …

Reports linking long‐term use of bisphosphonates (BPs) with atypical fractures of the femur
led the leadership of the American Society for Bone and Mineral Research (ASBMR) to …

Many biological tissues, such as wood and bone, are fiber composites with a hierarchical
structure. Their exceptional mechanical properties are believed to be due to a functional …