RNA-binding protein Rbm24 as a multifaceted post-transcriptional regulator of embryonic lineage differentiation and cellular homeostasis
R Grifone, M Shao, A Saquet, DL Shi - Cells, 2020 - mdpi.com
RNA-binding proteins control the metabolism of RNAs at all stages of their lifetime. They are
critically required for the post-transcriptional regulation of gene expression in a wide variety …
critically required for the post-transcriptional regulation of gene expression in a wide variety …
A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
H Choquet, RB Melles, D Anand, J Yin… - Nature …, 2021 - nature.com
Cataract is the leading cause of blindness among the elderly worldwide and cataract
surgery is one of the most common operations performed in the United States. As the …
surgery is one of the most common operations performed in the United States. As the …
RNA-binding proteins and post-transcriptional regulation in lens biology and cataract: Mediating spatiotemporal expression of key factors that control the cell cycle …
SA Lachke - Experimental eye research, 2022 - Elsevier
Abstract Development of the ocular lens–a transparent tissue capable of sustaining frequent
shape changes for optimal focusing power–pushes the boundaries of what cells can …
shape changes for optimal focusing power–pushes the boundaries of what cells can …
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology
JA Tangeman, SM Rebull, E Grajales-Esquivel… - …, 2024 - journals.biologists.com
Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause
congenital cataracts. We report the first single-cell multiomic atlas of lens development …
congenital cataracts. We report the first single-cell multiomic atlas of lens development …
High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology
Defects in the development of the ocular lens can cause congenital cataracts. To understand
the various etiologies of congenital cataracts, it is important to characterize the genes linked …
the various etiologies of congenital cataracts, it is important to characterize the genes linked …
Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects
SD Patel, D Anand, H Motohashi, F Katsuoka… - Frontiers in Cell and …, 2022 - frontiersin.org
Deficiency of the small Maf proteins Mafg and Mafk cause multiple defects, namely,
progressive neuronal degeneration, cataract, thrombocytopenia and mid …
progressive neuronal degeneration, cataract, thrombocytopenia and mid …
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation
C Tu, H Li, X Liu, Y Wang, W Li, L Meng, W Wang, Y Li… - Autophagy, 2021 - Taylor & Francis
In humans, TDRD7 (tudor domain containing 7) mutations lead to a syndrome combining
congenital cataracts (CCs) and non-obstructive azoospermia (NOA), characterized by …
congenital cataracts (CCs) and non-obstructive azoospermia (NOA), characterized by …
Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery
To expedite gene discovery in eye development and its associated defects, we previously
developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene …
developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene …
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and …
S Aryal, J Viet, BAT Weatherbee, AD Siddam… - Human genetics, 2020 - Springer
The homeodomain transcription factors (TFs) Pax6 (OMIM: 607108) and Prox1 (OMIM:
601546) critically regulate gene expression in lens development. While PAX6 mutations in …
601546) critically regulate gene expression in lens development. While PAX6 mutations in …
LOTUS-domain proteins-developmental effectors from a molecular perspective
J Kubíková, R Reinig, HK Salgania, M Jeske - Biological chemistry, 2020 - degruyter.com
The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found
in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the …
in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the …