The bacterial cell envelope

TJ Silhavy, D Kahne, S Walker - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The bacteria cell envelope is a complex multilayered structure that serves to protect these
organisms from their unpredictable and often hostile environment. The cell envelopes of …

Outer membrane biogenesis

A Konovalova, DE Kahne… - Annual review of …, 2017 - annualreviews.org
The hallmark of gram-negative bacteria and organelles such as mitochondria and
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …

Prospects for new antibiotics: a molecule-centered perspective

CT Walsh, TA Wencewicz - The Journal of antibiotics, 2014 - nature.com
There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Structural basis of outer membrane protein insertion by the BAM complex

Y Gu, H Li, H Dong, Y Zeng, Z Zhang, NG Paterson… - Nature, 2016 - nature.com
All Gram-negative bacteria, mitochondria and chloroplasts have outer membrane proteins
(OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative …

Importing mitochondrial proteins: machineries and mechanisms

A Chacinska, CM Koehler, D Milenkovic, T Lithgow… - Cell, 2009 - cell.com
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported
across one or both mitochondrial membranes. There is an amazingly versatile set of …

Structural insight into the biogenesis of β-barrel membrane proteins

N Noinaj, AJ Kuszak, JC Gumbart, P Lukacik, H Chang… - Nature, 2013 - nature.com
Abstract β-barrel membrane proteins are essential for nutrient import, signalling, motility and
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …

Outer membrane protein biogenesis in Gram-negative bacteria

SE Rollauer, MA Sooreshjani… - … Transactions of the …, 2015 - royalsocietypublishing.org
Gram-negative bacteria contain a double membrane which serves for both protection and for
providing nutrients for viability. The outermost of these membranes is called the outer …

Structure of a nascent membrane protein as it folds on the BAM complex

D Tomasek, S Rawson, J Lee, JS Wzorek, SC Harrison… - Nature, 2020 - nature.com
Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …

The structure of the β-barrel assembly machinery complex

J Bakelar, SK Buchanan, N Noinaj - Science, 2016 - science.org
β-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-
negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200 …

The β-barrel assembly machinery in motion

N Noinaj, JC Gumbart, SK Buchanan - Nature Reviews Microbiology, 2017 - nature.com
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …