Biodegradable pH-responsive micelles loaded with 8-hydroxyquinoline glycoconjugates for Warburg effect based tumor targeting
A Domiński, M Krawczyk, T Konieczny… - European Journal of …, 2020 - Elsevier
Biodegradable triblock copolymer poly (ethylene glycol)-b-polycarbonate-b-oligo ([R]-3-
hydroxybutyrate) was prepared via metal-free ring-opening polymerization of ketal protected …
hydroxybutyrate) was prepared via metal-free ring-opening polymerization of ketal protected …
TLR7 endogenous ligands remodel glycolytic macrophages and trigger skin‐to‐joint crosstalk in psoriatic arthritis
K Van Raemdonck, S Umar… - European journal of …, 2021 - Wiley Online Library
Thirty percent of psoriasis patients develop psoriatic arthritis (PsA), nevertheless the
mechanism remains unknown. Endogenous GU‐rich miRNAs activate endosomal TLR7 that …
mechanism remains unknown. Endogenous GU‐rich miRNAs activate endosomal TLR7 that …
[PDF][PDF] The Impact of Proinflammatory Cytokines and Imiquimod on GLUT1 in HaCaT Keratinocytes–a Potential Anti-Psoriatic Therapeutic Target?
S Makuch, P Kupczyk, A Makarec… - Cell Physiol …, 2023 - articles.cellphysiolbiochem.com
Abstract Background/Aims: Glucose metabolism has been proven as an essential process
for proliferating keratinocytes, which highlights the importance of glucose transporter-1 …
for proliferating keratinocytes, which highlights the importance of glucose transporter-1 …
In vitro and in vivo efficacy of a novel glucose–methotrexate conjugate in targeted cancer treatment
M Woźniak, G Pastuch-Gawołek, S Makuch… - International Journal of …, 2021 - mdpi.com
Methotrexate (MTX) is a commonly used antimetabolite, which inhibits folate and DNA
synthesis to be effective in the treatment of various malignancies. However, MTX therapy is …
synthesis to be effective in the treatment of various malignancies. However, MTX therapy is …
Phytochemical investigation, structural elucidation, in silico study and anti-psoriatic activity of potent bioactive from Betula utilis
Psoriasis is a chronic autoimmune pathological condition characterized by hyperactivation
of proinflammatory cytokines (IL-6, TNF-α, IL-17, IL-23, etc.). Severe drug-associated …
of proinflammatory cytokines (IL-6, TNF-α, IL-17, IL-23, etc.). Severe drug-associated …
Pithecellobium clypearia: Amelioration Effect on Imiquimod-Induced Psoriasis in Mice Based on a Tissue Metabonomic Analysis
Y Li, J Zong, W Ye, Y Fu, X Gu, W Pan… - Frontiers in …, 2021 - frontiersin.org
Pithecellobium clypearia Benth.(accepted name: Archidendron clypearia (Jack) IC Nielsen;
Mimosaceae), a popular traditional Chinese medicine, has a significant anti-inflammatory …
Mimosaceae), a popular traditional Chinese medicine, has a significant anti-inflammatory …
In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar–Zinc Phthalocyanine Conjugates
Psoriasis, a chronic immune-mediated skin disorder affecting over 125 million people
globally, is characterized by abnormal keratinocyte proliferation and immune cell infiltration …
globally, is characterized by abnormal keratinocyte proliferation and immune cell infiltration …
[HTML][HTML] Dysregulated dermal mesenchymal stem cell proliferation and differentiation interfered by glucose metabolism in psoriasis
X Zhao, J Xing, J Li, R Hou, X Niu… - … Journal of Stem …, 2021 - synapse.koreamed.org
Methods and Results We found that the OCR of DMSCs in psoriatic lesions was higher than
that in the control group, and mRNA of GLUT1 and HK2 were up-regulated compared with …
that in the control group, and mRNA of GLUT1 and HK2 were up-regulated compared with …
[HTML][HTML] The impact of glucose conjugation on the activity and uptake of zinc phthalocyanine in HaCaT keratinocytes stimulated with proinflammatory cytokines
S Makuch, P Ziółkowski, M Woźniak - Photodiagnosis and Photodynamic …, 2024 - Elsevier
Significance Glucose metabolism has been proven as an essential process for proliferating
keratinocytes, which highlights the importance of glucose transporter-1 (GLUT1) not only in …
keratinocytes, which highlights the importance of glucose transporter-1 (GLUT1) not only in …
Developments in carbohydrate-based metzincin inhibitors
Matrix metalloproteinases (MMPs) and A disintegrin and Metalloproteinase (ADAMs) are
zinc-dependent endopeptidases belonging to the metzincin superfamily. Upregulation of …
zinc-dependent endopeptidases belonging to the metzincin superfamily. Upregulation of …