Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions
Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as a central target for cancer
therapies due to the ability of PARP inhibitors to specifically kill tumors deficient for DNA …
therapies due to the ability of PARP inhibitors to specifically kill tumors deficient for DNA …
Single-molecule analysis of transcription activation: dynamics of SAGA co-activator recruitment
J Jeon, LJ Friedman, HD Seo, A Adeleke, B Graham… - bioRxiv, 2023 - biorxiv.org
Transcription activators are said to stimulate gene expression by" recruiting" coactivators to
promoters, yet this term fits several different kinetic models. To directly analyze dynamics of …
promoters, yet this term fits several different kinetic models. To directly analyze dynamics of …