Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …

Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Mutation of the TP53 tumor suppressor gene is the most common genetic alteration in
cancer, and almost 1000 alleles have been identified in human tumors. While virtually all …

The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …

SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in
physiology and disease are believed to be linked to its role as a master regulator of …

Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …

KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic
response that promotes hypovascularity, immunosuppression, and resistance to chemo-and …