Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several
risk factors including unhealthy lifestyle, genetic background, obesity, diabetes …

The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism.
Indoleamine 2, 3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting …

The recent outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China has spread
rapidly around the world, leading to a widespread and urgent effort to develop and use …

Mounting evidence demonstrates that kynurenine metabolism may play an important
pathogenic role in the development of multiple neurological and neuropsychiatric disorders …

(L-) tryptophan is metabolized via the kynurenine pathway into several kynurenine
metabolites with distinct functions. Dysfunction of the kynurenine pathway can lead to …

Scientific interest in tryptophan metabolism via the kynurenine pathway (KP) has increased
in the last decades. Describing its metabolites helped to increase their roles in many …

This review discusses the mechanisms and consequences of degradation of tryptophan
(Trp) in the placenta, focusing mainly on the role of indoleamine 2, 3-dioxygenase-1 (IDO1) …

In this review, we explore the role of dendritic cell subsets in the development of tissue‐
specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is …