Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Parkinson's disease is the second most common neurodegenerative disease and yet the
early pathophysiological events of the condition and sequences of dysfunction remain …

In Lewy body diseases—including Parkinson's disease, without or with dementia, dementia
with Lewy bodies, and Alzheimer's disease with Lewy body co-pathology—α-synuclein (α …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

In 2017, it is two hundred years since James Parkinson provided the first complete clinical
description of the disease named after him, fifty years since the introduction of high-dose D …