Many intracellular pathogens, including the protozoan parasite Toxoplasma gondii, live
inside a vacuole that resides in the host cytosol. Vacuolar residence provides these …

Like many intracellular pathogens, the protozoan parasite Toxoplasma gondii has evolved
sophisticated mechanisms to promote its transmission and persistence in a variety of hosts …

Genome-wide CRISPR screening is a powerful tool to identify genes required under
selective conditions. However, the inherent scale of genome-wide libraries can limit their …

Toxoplasma gondii is an obligate intracellular parasite that establishes a favorable
environment in the host cells in which it replicates. We have previously reported that it uses …

Toxoplasma gondii is a ubiquitous, intracellular protozoan that extensively modifies infected
host cells through secreted effector proteins. Many such effectors must be translocated …

Toxoplasma gondii infects approximately 30% of the world's population, causing disease
primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma …

Toxoplasma gondii tachyzoites co-opt host cell functions through introduction of a large set
of rhoptry-and dense granule-derived effector proteins. These effectors reach the host …

After differentiation is triggered, the tachyzoite-stage Toxoplasma gondii parasitophorous
vacuole membrane (PVM) has been hypothesized to transition into the cyst membrane that …

During host cell invasion, the eukaryotic pathogen Toxoplasma gondii forms a
parasitophorous vacuole to safely reside within the cell, while it is partitioned from host cell …

Manipulation of the host cell is a crucial part of life for many intracellular organisms. We have
recently come to appreciate the extent to which the intracellular pathogen Toxoplasma …