Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Background The current genome-wide association study (GWAS) of Lewy body dementia
(LBD) suffers from low power due to a limited sample size. In addition, the genetic …

Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse
prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human …

Primary age-related tauopathy (PART) is a neurodegenerative pathology with features
distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer …

Loneliness and social isolation are detrimental to mental health and may lead to cognitive
impairment and neurodegeneration. Although several molecular signatures of loneliness …

Neuroimaging in the preclinical phase of Alzheimer's disease provides information crucial to
early intervention, particularly in people with a high genetic risk. Metabolic network …

Vast numbers of differentially expressed genes and perturbed networks have been identified
in Alzheimer's disease (AD), however, neither disease nor brain region specificity of these …

Tauopathies are a heterogeneous group of neurologic diseases characterized by
pathological axodendritic distribution, ectopic expression, and/or phosphorylation and …

Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in
Alzheimer's disease (AD) dementia and is a common finding at autopsy. The APOE ε4 allele …

INTRODUCTION DNA microarray‐based studies report differentially methylated positions
(DMPs) in blood between late‐onset dementia due to Alzheimer's disease (AD) and …