Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Plasmodium falciparum, the human malaria parasite, infects two hosts and various cell
types, inducing distinct morphological and physiological changes in the parasite in response …

Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

For its replication within red blood cells, the malaria parasite depends on a highly active and
regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as …

Taxon-specific proteins are key determinants defining the biology of all organisms and
represent prime drug targets in pathogens. However, lacking comparability with proteins in …

Iron is essential to cells as a cofactor in enzymes of respiration and replication, however
without correct storage, iron leads to the formation of dangerous oxygen radicals. In yeast …

Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced
susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work …

The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which
confers stability and shape to the cell, functions as a scaffolding compartment during the …

The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …

Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and
survival of the human malaria parasite Plasmodium (P.) falciparum. Bromodomain proteins …