Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation

AM Bratt‐Leal, RL Carpenedo… - Biotechnology …, 2009 - Wiley Online Library
Embryonic stem cells (ESCs) are pluripotent cells capable of differentiating into all somatic
and germ cell types. The intrinsic ability of pluripotent cells to generate a vast array of …

Stem cell insights into human trophoblast lineage differentiation

TKJB Gamage, LW Chamley… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND The human placenta is vital for fetal development, yet little is understood
about how it forms successfully to ensure a healthy pregnancy or why this process is …

Quantitative single-cell RNA-seq with unique molecular identifiers

S Islam, A Zeisel, S Joost, G La Manno, P Zajac… - Nature …, 2014 - nature.com
Single-cell RNA sequencing (RNA-seq) is a powerful tool to reveal cellular heterogeneity,
discover new cell types and characterize tumor microevolution. However, losses in cDNA …

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

AJ Keung, P Asuri, S Kumar, DV Schaffer - Integrative Biology, 2012 - academic.oup.com
Human pluripotent stem cells (hPSCs) are of great interest in biology and medicine due to
their ability to self-renew and differentiate into any adult or fetal cell type. Important efforts …

[HTML][HTML] Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells

AW Leung, DK Morest, JYH Li - Developmental biology, 2013 - Elsevier
Sensory and endoneurocrine tissues as diverse as the lens, the olfactory epithelium, the
inner ear, the cranial sensory ganglia, and the anterior pituitary arise from a common pool of …

Analysis of co-expression of OCT4, NANOG and SOX2 in pluripotent cells of the porcine embryo, in vivo and in vitro

L du Puy, SMC de Sousa Lopes, HP Haagsman… - Theriogenology, 2011 - Elsevier
To derive porcine embryonic stem (ES) cell lines, the time window during which porcine
embryos contain pluripotent cells that are predisposed to undifferentiated self-renewal in …

Neuro-mesodermal progenitors (NMPs): a comparative study between pluripotent stem cells and embryo-derived populations

S Edri, P Hayward, W Jawaid… - Development, 2019 - journals.biologists.com
The mammalian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors,
called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the …

[HTML][HTML] Human Induced Pluripotent Stem Cell–Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo

O Veraitch, T Kobayashi, Y Imaizumi… - Journal of Investigative …, 2013 - Elsevier
Well-orchestrated epithelial–mesenchymal interactions are crucial for hair follicle (HF)
morphogenesis. In this study, ectodermal precursor cells (EPCs) with the capacity to cross …

Transcriptome analysis reveals new insights into the modulation of endometrial stromal cell receptive phenotype by embryo-derived signals interleukin-1 and human …

A Bourdiec, E Calvo, CV Rao, A Akoum - PLoS One, 2013 - journals.plos.org
The presence of the conceptus in uterine cavity necessitates an elaborate network of
interactions between the implanting embryo and a receptive endometrial tissue. We believe …

Collagen/β1 integrin interaction is required for embryoid body formation during cardiogenesis from murine induced pluripotent stem cells

D Zeng, DB Ou, T Wei, L Ding, XT Liu, XL Hu, X Li… - BMC cell biology, 2013 - Springer
Background The interactions between stem cells and extracellular matrix (ECM) mediated
by integrins play important roles in the processes that determine stem cell fate. However, the …