Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …

The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four
members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted …

The segmentation clock is an oscillating genetic network thought to govern the rhythmic and
sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling
plays essential roles in processes across species. The roles of Wnt signaling proteins and …

WNT signalling has a key role in early embryonic patterning through the regulation of cell
fate decisions, tissue polarity and cell movements. In the nervous system, WNT signalling …

Neuraxial patterning is a continuous process that extends over a protracted period of
development. During gastrulation a crude anteroposterior pattern, detectable by molecular …

Wnt/β-catenin signaling is central to bone development and homeostasis in adulthood and
its deregulation is associated with bone pathologies. Dickkopf-1 (DKK1), a soluble inhibitor …