The immune system's role is much more than merely recognizing self vs. non-self and
involves maintaining homeostasis and integrity of the organism starting from early …

Depressive disorders are complex, multifactorial disorders that have been traditionally
attributed exclusively to neuronal abnormalities. However, recent studies have increased …

Background Brain innate immunity is vital for maintaining normal brain functions. Immune
homeostatic imbalances play pivotal roles in the pathogenesis of neurological diseases …

Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder for which
available medications are often not effective. The high prevalence of MDD and modest …

Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic
spinal contusion injury in mice, a benefit achieved in part by reducing macrophage …

Oligodendrocytes and their progenitors are glial cells in the central nervous system, which
have been mainly implicated with the homeostatic roles of axonal myelin ensheathment but …

Background Multiple sclerosis (MS) therapeutic goals have traditionally been dichotomized
into two distinct avenues: immune-modulatory-centric interventions and pro-regenerative …

When seen in its entirety, the animal model experimental autoimmune encephalomyelitis
(EAE) bears signifi‑cant similarities to multiple sclerosis (MS) and its different varieties …

The extracellular matrix (ECM) is a fundamental component of biological tissues. The ECM
in the central nervous system (CNS) is unique in both composition and function. Functions …

Central nervous system diseases involving the parenchymal microvessels are frequently
associated with a 'microvasculopathy', which includes different levels of neurovascular unit …