Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Abstract The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It
is a highly conserved evolutionary pathway of signal transmission from the cell membrane to …

It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Identification of risk variants for neuropsychiatric diseases within enhancers underscores the
importance of understanding population-level variation in enhancer function in the human …

A diffusion barrier at the transition zone enables the compartmentalization of signaling
molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …