Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease
BR De Miranda, JT Greenamyre - Environmental Science: Processes & …, 2020 - pubs.rsc.org
Organic solvents are common chemicals used in industry throughout the world, however,
there is evidence for adverse health effects from exposure to these compounds …
there is evidence for adverse health effects from exposure to these compounds …
Model systems and organisms for addressing inter-and intra-species variability in risk assessment
Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …
remains a long-standing challenge in human health risk assessment that is typically …
Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve …
Background: Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority
chemicals subject to numerous human health risk evaluations by a range of agencies …
chemicals subject to numerous human health risk evaluations by a range of agencies …
[HTML][HTML] Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species …
L Capinha, P Jennings, JNM Commandeur - Toxicology Letters, 2021 - Elsevier
Enzymatic conjugation of glutathione (GSH) to trichloroethylene (TCE) followed by
catabolism to the corresponding cysteine-conjugate, S-(dichlorovinyl)-L-cysteine (DCVC) …
catabolism to the corresponding cysteine-conjugate, S-(dichlorovinyl)-L-cysteine (DCVC) …
Metabolism and toxicity of trichloroethylene and tetrachloroethylene in cytochrome P450 2E1 knockout and humanized transgenic mice
YS Luo, S Furuya, VY Soldatov, O Kosyk… - Toxicological …, 2018 - academic.oup.com
Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that
can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with …
can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with …
Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models
ER Elkin, AL Su, BA Kilburn, KM Bakulski… - Reproductive …, 2022 - Elsevier
Residential and occupational exposures to the industrial solvents perchloroethylene (PERC)
and trichloroethylene (TCE) present public health concerns. In humans, maternal PERC and …
and trichloroethylene (TCE) present public health concerns. In humans, maternal PERC and …
Using collaborative cross mouse population to fill data gaps in risk assessment: a case study of population-based analysis of toxicokinetics and kidney toxicodynamics …
Background: Interindividual variability in susceptibility remains poorly characterized for
environmental chemicals such as tetrachloroethylene (PERC). Development of population …
environmental chemicals such as tetrachloroethylene (PERC). Development of population …
Population-based analysis of DNA damage and epigenetic effects of 1, 3-butadiene in the mouse
L Lewis, B Borowa-Mazgaj, A de Conti… - Chemical research in …, 2019 - ACS Publications
Metabolism of 1, 3-butadiene, a known human and rodent carcinogen, results in formation of
reactive epoxides, a key event in its carcinogenicity. Although mice exposed to 1, 3 …
reactive epoxides, a key event in its carcinogenicity. Although mice exposed to 1, 3 …
Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains
Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar chemicals
that are metabolized through oxidation and glutathione conjugation pathways. Both …
that are metabolized through oxidation and glutathione conjugation pathways. Both …
Population-based dose–response analysis of liver transcriptional response to trichloroethylene in mouse
Studies of gene expression are common in toxicology and provide important clues to
mechanistic understanding of adverse effects of chemicals. Most prior studies have been …
mechanistic understanding of adverse effects of chemicals. Most prior studies have been …